منابع مشابه
Oncogenes and radiation carcinogenesis.
Current research indicates a role for several oncogenes in radiation-induced carcinogenesis in vivo and cell transformation in vitro. Certain oncogenes are probably also involved in some cases of human cancer caused by exposure to nonionizing radiation and may play a mechanistic role in the phenomenon of radioresistance seen in later stages of tumor progression. The mechanisms of oncogene activ...
متن کاملIn Vivo Dna Repair Mechanisms and Carcinogenesis
Understanding how DNA repair deficiencies predispose cells to damage accumulation and mutation is particularly important to understanding the carcinogenic process. In the first theme (Theme I) of this work, two types of base excision repair (BER) deficiencies are explored. In the first study (Theme IA), we observed a significant decrease in BER activity in liver tissues during acute hepatitis i...
متن کاملUV damage, DNA repair and skin carcinogenesis.
Skin cancer is unique among human cancers in its etiology, accessibility and the volume of detailed knowledge now assembled concerning its molecular mechanisms of origin. The major carcinogenic agent for most skin cancers is well established as solar ultraviolet light. This is absorbed in DNA with the formation of UV-specific dipyrimidine photoproducts. These can be repaired by nucleotide excis...
متن کاملTransforming ras oncogenes and multistage carcinogenesis.
Transforming ras oncogenes and multistage carcinogenesis Few topics have caught the imagination of both clinicians and scientists in the field of cancer research as readily as the recent studies on oncogenes and their role in tumour development. The first identification of transforming genes in human tumours (Der et al., 1982; Parada et al., 1982; Santos et al., 1982) was greeted in certain cir...
متن کاملThe role of oncogenes in chemical carcinogenesis.
Proto-oncogenes are cellular genes that are expressed during normal growth and developmental processes. Altered versions of normal proto-oncogenes have been implicated in the development of human neoplasia. In this report, we show the detection of activated proto-oncogenes in various spontaneous and chemically induced rodent tumors. The majority of activated proto-oncogenes found in these tumor...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1988
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/9.5.691